Abstract
The synthesis and biological evaluation of a series of oxindole beta(3) adrenergic receptor agonists is described. A modulation of rat atrial tachycardia was observed with substitution at the 3-position of the oxindole moiety.
MeSH terms
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Adrenergic beta-3 Receptor Agonists*
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Adrenergic beta-Agonists / chemical synthesis*
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Adrenergic beta-Agonists / chemistry
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Adrenergic beta-Agonists / pharmacology*
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Animals
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CHO Cells
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Cricetinae
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Cricetulus
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Disease Models, Animal
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Drug Evaluation, Preclinical
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Humans
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Indoles / chemical synthesis*
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Indoles / chemistry
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Indoles / pharmacology*
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Molecular Structure
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Oxindoles
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Rats
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Rats, Long-Evans
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Receptors, Adrenergic, beta-3 / biosynthesis
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Receptors, Adrenergic, beta-3 / genetics
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Tachycardia / drug therapy*
Substances
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Adrenergic beta-3 Receptor Agonists
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Adrenergic beta-Agonists
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Indoles
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Oxindoles
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Receptors, Adrenergic, beta-3
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2-oxindole